The OIS Index Consists of Publicly Traded Small and Mid-Cap Growth Companies in Ophthalmology

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We introduced the OIS Index, a composite of ophthalmic growth stocks, in October 2016 at OIS@AAO with the purpose of tracking the performance of our sector. The components of the OIS Index are publicly traded small- and mid-cap growth companies in ophthalmology that derive at least half of their value from ophthalmic products and technology. The index was launched with a base value of 1,000. The index is weighted about 65% biopharma and 35% ophthalmic device, based on company valuations. Company market caps range from $10 million to $9 billion, with a median of $250 million.

OIS Index

December 1, 2018


Index Performance (% Chg.)1 Month3 Months1 Year
OIS Index (OIS)-2.3%-22.8%0.1%
NASDAQ Biotechnology Index (NBI)4.7%-10.8%3.7%
US Medical Device Index (IHI)5.5%-1.5%21.9%
US Market: Russell 3000 Index (R3000)1.8%-5.8%3.6%

OIS Index - Three Month Performance

August 31, 2018 - November 30, 2018

Index values are scaled to 100 as of the initial date in the chart.

OIS Index - One Year Performance

November 30, 2017 - November 30, 2018

Index values are scaled to 100 as of the initial date in the chart.

OIS Index Components

Adverum Biotechnologies Inc.
Aerie Pharmaceuticals Inc.
Aldeyra Therapeutics Inc.
Alimera Sciences Inc.
Apellis Pharmaceuticals, Inc.
Applied Genetic Technologies Corp.
Bausch Health
Carl Zeiss Meditec AG
Clearside Biomedical, Inc.
Ellex Medical Lasers Ltd.
EyeGate Pharmaceuticals, Inc.
EyePoint Pharmaceuticals
GenSight Biologics SA
Glaukos Corp.
Imprimis Pharmaceuticals Inc.
Iridex Corp.
Kala Pharmaceuticals
KalVista Pharmaceuticals Ltd.
Molecular Partners AG
Nicox SA
Nightstar Therapeutics
NovaBay Pharmaceuticals Inc.
Ocular Therapeutix Inc.
Ohr Pharmaceuticals Inc.
Omeros Corp.
Opthea Ltd.
Ophthotech Corp.
Presbia PLC
Second Sight Medical Products Inc.
Spark Therapeutics Inc.
STAAR Surgical Co.
UNITY Biotechnology