The OIS Index Consists of Publicly Traded Small and Mid-Cap Growth Companies in Ophthalmology

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We introduced the OIS Index, a composite of ophthalmic growth stocks, in October 2016 at OIS@AAO with the purpose of tracking the performance of our sector. The components of the OIS Index are publicly traded small- and mid-cap growth companies in ophthalmology that derive at least half of their value from ophthalmic products and technology. The index was launched with a base value of 1,000. The index is weighted about 65% biopharma and 35% ophthalmic device, based on company valuations. Company market caps range from $10 million to $9 billion, with a median of $250 million.

OIS Index

June 1, 2019


Index Performance (% Chg.)1 Month3 Months1 Year
OIS Index (OIS)-4.1%-1.2%4.0%
NASDAQ Biotechnology Index (NBI)-6.1%-11.4%-7.9%
US Medical Device Index (IHI)-1.9%-2.5%11.5%
US Market: Russell 3000 Index (R3000)-6.7%-1.8%0.6%

OIS Index - Three Month Performance

February 28, 2019 - May 31, 2019

Index values are scaled to 100 as of the initial date in the chart.

OIS Index - One Year Performance

May 31, 2018 - May 31, 2019

Index values are scaled to 100 as of the initial date in the chart.

OIS Index Components

Adverum Biotechnologies Inc.
Aerie Pharmaceuticals Inc.
Aerpio Pharmaceuticals
Aldeyra Therapeutics Inc.
Alimera Sciences Inc.
Apellis Pharmaceuticals, Inc.
Applied Genetic Technologies Corp.
Bausch Health
Carl Zeiss Meditec AG
Clearside Biomedical, Inc.
Ellex Medical Lasers Ltd.
EyeGate Pharmaceuticals, Inc.
EyePoint Pharmaceuticals
GenSight Biologics SA
Glaukos Corp.
Harrow Health
Iridex Corp.
Kala Pharmaceuticals
KalVista Pharmaceuticals Ltd.
Molecular Partners AG
Nicox SA
Nightstar Therapeutics
NovaBay Pharmaceuticals Inc.
Ocular Therapeutix Inc.
Omeros Corp.
Opthea Ltd.
Second Sight Medical Products Inc.
Spark Therapeutics Inc.
STAAR Surgical Co.
UNITY Biotechnology