Posts Tagged ‘AMD’

Is AMD Drug-Treatment Landscape Shifting?

Is AMD Drug-Treatment Landscape Shifting?

When Novartis last week announced positive outcomes from two Phase III trials for new age-related macular degeneration (AMD) drug brolucizumab (RTH258), it seemed the other two major players in the AMD space – Regeneron and Roche – might lose some of their luster. But Regeneron’s stock kept gaining ground despite the potential threat of four-times-a-year…

Read More

With Positive Phase I/IIa, Opthea Looks to Next Step

With Positive Phase I/IIa, Opthea Looks to Next Step

Coming off word that the Phase I/IIa clinical trial of its novel anti-VEGF candidate for treatment of age-related macular degeneration exceeded expectations, along with positive regulatory agency feedback and a new round of fundraising, Australia-based Opthea is looking to expand its Phase IIb trial and explore the application of its lead candidate in other ocular…

Read More

How Regeneron Aims to Stay on Message With VR/AR APP

How Regeneron Aims to Stay on Message with VR/AR App

Virtual reality has been used to train surgeons, to evaluate balance control and associated fall risk in glaucoma patients, and, more recently, to create simulations that allow users to better understand the visual effects of various eye diseases. To the latter, Regeneron and Intouch Solutions have developed and released the In My Eyes smartphone app.…

Read More

After Stunning Phase III Results, Ophthotech Seeks a Path Forward

Eye On Innovation Article - After stunning Phase 3 results, Ophthotech seeks a path forward - Healthegy

After disappointing Phase III results of Fovista (pegpleranib) in combination with Lucentis (ranibizumab, Genentech) sent its stock reeling, Ophthotech Corporation is reevaluating not only the trial data but also how the results will impact ongoing Fovista combination trials as well as its overall business. And while Ophthotech may have the equivalent of financial pneumonia, if…

Read More

Graybug Could File GB-102 IND Next Year

Jeffrey Cleland, president and CEO, Graybug Vision, delivered an update on its two treatments for wet age-related macular degeneration (Wet AMD) and glaucoma. The company is working with an approved cancer treatment, Sutent, which has demonstrated the ability to restore vision in patients who also suffer from Wet AMD. An animal study of the company’s…

Read More

Aerie: Moving Beyond Glaucoma

Most ophthalmologists are aware that Aerie Pharmaceuticals is developing Rho-kinase and norepinephrine transporter inhibitors (Rhopressa, or netarsudil) for the treatment of glaucoma, and that the company plans on filing its first NDA by the end of the quarter. Another product combines Rhopressa with leading glaucoma prostaglandin treatment latanoprost; that treatment is in phase 3 development.…

Read More

Regeneron: Pursuing Combination Therapies with PDGFR-beta and Ang2

Regeneron Pharmaceuticals Inc. markets the highly successful anti-VEGF injection EYLEA (aflibercept), which is FDA approved for neovascular (wet) age-related macular degeneration (AMD), macular edema following retinal vein occlusion (RVO), and diabetic macular edema (DME) and diabetic retinopathy (DR) in patients with DME. Global EYLEA sales in 2015 totaled $4.1 billion, including OUS sales by Bayer.…

Read More

Aerpio Therapeutics: Focus on Tie2 Activation

Aerpio Therapeutics is focused on the development of novel therapeutics for vascular disorders, with a concentration on eye diseases. Joseph Gardner, CEO of Aerpio, provided an overview of the company’s approach to addressing retinal diseases through activation of Tie2, a tyrosine kinase receptor. “Tie2 is now widely published as being one of the most important…

Read More

Allegro Ophthalmics: First-in-Class Anti-Integrin Agent

Allegro Ophthalmics is developing Luminate, a first-in-class anti-integrin peptide with a novel mechanism of action for both anti-angiogenesis and vitreolysis. The company is in late-stage development with multiple programs in Phase IIb or later. According to Vicken Karageozian, MD, president of Allegro, about 400 human eyes have been treated with about 1,000 intravitreal injections to…

Read More

Retina Experts Serve Up a Combination Platter at OIS@ASRS

Contributed By: Michael Lachman The OIS@ASRS panel discussion on Emerging Approaches to Combination Therapies in AMD & DME was moderated by Mark Humayan, MD, PhD, director of the USC Eye Institute, and Emmett T. Cunningham, Jr., MD, PhD, MPH, of Clarus Ventures. The need for new treatment approaches was articulated by Pravin Dugel, MD, Arizona-based…

Read More

Google–Moorfields Venture Eyes AI to Speed Diagnosis with OCT

Google–Moorfields Venture Eyes AI to Speed Diagnosis with OCT

Google’s DeepMind Health artificial intelligence project and Moorfields Eye Hospital in London have teamed up for a five-year venture to develop an algorithm using one million anonymized retina scans from the Moorfields’ database to speed up and improve diagnosis of age-related macular degeneration (AMD) and diabetic retinopathy. Google and Moorfields announced the collaboration this month.…

Read More